There currently is one option to travel by night bus from Rome (Italy) to Prague (Czech Republic), taking approximately 20 hours: Namely the BUS Řím - Praha operated by Regiojet.

Next offers

Regiojet operates both night trains and night buses across Europe, providing various travel options. Their night trains feature several types of cabins, including seats that can recline slightly for added comfort, as well as private sleeping couchettes that accommodate one to four passengers, equipped with bedding and duvets. Wifi is available and breakfast and coffee are complimentary. Regiojet night buses feature ergonomic seating that can recline for comfort, with generous legroom and amenities such as USB charging ports, free WiFi, personal entertainment screens, and complimentary refreshments available during the journey. There is also a toilet on the bus.

For the next 7 dates with connections, the cheapest offer starts at 50 EUR. Check our connection pages below for all availabilities!

Offers on the date of your choice

Next available offers

Sun, 27.04.2025

from 64 EUR

Wed, 30.04.2025

from 56 EUR

Sun, 04.05.2025

from 56 EUR

Wed, 07.05.2025

from 64 EUR

Sun, 11.05.2025

from 56 EUR

Wed, 14.05.2025

from 50 EUR

Sun, 18.05.2025

from 50 EUR